Description:
A gene that makes a protein involved in controlling cell growth, division, and death. This protein may also play a role in repairing damaged DNA and controlling the activity of certain genes. Mutations (changes) in the BAP1 gene may cause abnormal cells, including cancer cells, to grow and spread in the body. BAP1 gene mutations have been found in an inherited condition called BAP1 tumor predisposition syndrome, which causes an increased risk of some types of cancer, including cancers of the skin, eye, kidney, bile duct, and mesothelium (the tissue that lines the chest and abdomen). The BAP1 gene is a type of tumor suppressor gene.
